What is FISH ?

FISH is an acronym for Flourescence In Situ Hybridization. 
 The technique works by using fluorescently labeled pieces of DNA (called probes), which bind specifically to the unique sequence of DNA adjacent to each telomere. These probes emit a colored fluorescent signal that can be detected and analyzed by specially equipped microscopes.  We expect to see two color signals for each telomere for an individual chromosome pair.  If material is missing so that there is only copy of a telomere for a specific pair, or monosomy, we will see only one signal.  If extra material is present so that 3 copies of a telomere for a specific pair is present, or trisomy, we will see three signals.

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***********************************Discuss Vysis probe set************************************
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